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Article

EGFR mutant-specific immunohistochemistry has high specificity and sensitivity for detecting targeted activating EGFR mutations in lung adenocarcinoma.

Journal of clinical pathology - 1 Sept 2013

Cooper W A, Yu B, Yip P Y, Ng C C, Lum T, Farzin M, Trent R J, Mercorella B, Clarkson A, Kohonen-Corish M R J, Horvath L G, Kench J G, McCaughan B, Gill A J, O'Toole S A

Abstract excerpt

AIM: We assessed the diagnostic accuracy of epidermal growth factor receptor (EGFR) mutant-specific antibodies for detecting two common activating EGFR mutations. METHODS: Immunohistochemical expression of mutation-specific antibodies against EGFR exon 19 deletion E746-A750 ((c.2235_2249del15 or c.2236_2250del15, p. Glu746_Ala750del) and exon 21 L858R point mutation (c.2573T>G, p.Leu858Arg) were assessed in a...

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Identifiers

PMID: 23757037
DOI: 10.1136/jclinpath-2013-201607

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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