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Article

Arterial klotho expression and FGF23 effects on vascular calcification and function.

PloS one - 1 Jan 2013

Lindberg Karolina, Olauson Hannes, Amin Risul, Ponnusamy Arvind, Goetz Regina, Taylor Rebecca F, Mohammadi Moosa, Canfield Ann, Kublickiene Karolina, Larsson Tobias E

Abstract excerpt

Recent studies support a role for FGF23 and its co-receptor Klotho in cardiovascular pathology, yet the underlying mechanisms remain largely elusive. Herein, we analyzed the expression of Klotho in mouse arteries and generated a novel mouse model harboring a vascular smooth muscle cell specific deletion of Klotho (Sm22-KL(-/-) ). Arterial Klotho expression was detected at very low levels with quantitative...

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Source

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Identifiers

PMID: 23577141
DOI: 10.1371/journal.pone.0060658
PMCID: PMC3618102

Genes

FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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