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Article

Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans.

Mutagenesis - 1 Sept 2008

Nakamura Nobuya, Morinaga Hironobu, Kikuchi Masahiro, Yonekura Shin-Ichiro, Ishii Naoaki, Yamamoto Kazuo, Yonei Shuji, Zhang Qiu-Mei

Abstract excerpt

Uracil arises in DNA from spontaneous deamination of cytosine and through incorporation of dUMP by DNA polymerase during DNA replication. Excision of uracil by the action of uracil-DNA glycosylase (Ung) initiates the base excision repair pathway to counter the promutagenic base modification. In this study, we cloned a cDNA-encoding Caenorhabditis elegans homologue (CeUng-1) of Escherichia coli Ung. There was 49%...

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Identifiers

PMID: 18524757
DOI: 10.1093/mutage/gen030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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