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NDX-1 protein hydrolyzes 8-oxo-7, 8-dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans.

Journal of biochemistry - 1 Dec 2011

Sanada U, Yonekura Shin-Ichiro, Kikuchi Masahiro, Hashiguchi Kazunari, Nakamura Nobuya, Yonei Shuji, Zhang-Akiyama Qiu-Mei

Abstract excerpt

8-oxo-dGTP is generated in the nucleotide pool by direct oxidation of dGTP or phosphorylation of 8-oxo-dGDP. It can be incorporated into DNA during replication, which would result in mutagenic consequences. The frequency of spontaneous mutations remains low in cells owing to the action of enzymes degrading such mutagenic substrates. Escherichia coli MutT and human MTH1 hydrolyze 8-oxo-dGTP to 8-oxo-dGMP. Human...

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PMID: 21873335
DOI: 10.1093/jb/mvr107

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NUDT5

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