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Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity.

Nucleic acids research - 2 Jun 2017

Chembazhi Ullas Valiya, Patil Vinod Vikas, Sah Shivjee, Reeve Wayne, Tiwari Ravi P, Woo Euijeon, Varshney Umesh

Abstract excerpt

Repair of uracils in DNA is initiated by uracil DNA glycosylases (UDGs). Family 1 UDGs (Ung) are the most efficient and ubiquitous proteins having an exquisite specificity for uracils in DNA. Ung are characterized by motifs A (GQDPY) and B (HPSPLS) sequences. We report a novel dimeric UDG, Blr0248 (BdiUng) from Bradyrhizobium diazoefficiens. Although BdiUng contains the motif A (GQDPA), it has low sequence...

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Identifiers

PMID: 28369586
DOI: 10.1093/nar/gkx209
PMCID: PMC5449639

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