Article
Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.
DNA repair - 2 Dec 2004
Jurado Juan, Maciejewska Agnieszka, Krwawicz Joanna, Laval Jacques, Saparbaev Murat K
Abstract excerpt
The 3,N(4)-ethenocytosine (epsilon C) residue might have biological role in vivo since it is recognized and efficiently excised in vitro by the E. coli mismatch-specific uracil-DNA glycosylase (MUG) and the human thymine-DNA glycosylase (hTDG). In the present work we have generated mug defective mutant of E. coli by insertion of a kanamycin cassette to assess the role of MUG in vivo. We show that human TDG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
