Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.

doi:10.1161/ATVBAHA.115.306973

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Article

Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Grandoch Maria, Kohlmorgen Christina, Melchior-Becker Ariane, Feldmann Kathrin, Homann Susanne, Müller Julia, Kiene Lena-Sophia, Zeng-Brouwers Jinyang, Schmitz Friederike, Nagy Nadine, Polzin Amin, Gowert Nina S, Elvers Margitta, Skroblin Philipp, Yin Xiaoke, Mayr Manuel, Schaefer Liliana, Tannock Lisa R, Fischer Jens W

Abstract excerpt

OBJECTIVE: Thrombin signaling promotes atherosclerosis by initiating inflammatory events indirectly through platelet activation and directly via protease-activated receptors. Therefore, endogenous thrombin inhibitors may be relevant modulators of atheroprogression and cardiovascular risk. In addition, endogenous thrombin inhibitors may affect the response to non-vitamin K-dependent oral anticoagulants. Here, the...

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PMID: 27034473
DOI: 10.1161/ATVBAHA.115.306973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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