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Article

T-bet plays a key role in NK-mediated control of melanoma metastatic disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2008

Werneck Miriam B F, Lugo-Villarino Geanncarlo, Hwang Eun Sook, Cantor Harvey, Glimcher Laurie H

Abstract excerpt

Antitumor responses depend on type 1 immunity, which is severely impaired in mice deficient for the T-box expressed in T cells (T-bet) transcription factor. Both T-bet-deficient (T-bet(-/-)) NK and CTL show defective function, which can be overcome by strong stimuli due to the expression of eomesodermin, another member of the T-box family. The effective response from T-bet(-/-) mice to viral infection and tumor...

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Source

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Identifiers

PMID: 18523263
DOI: 10.4049/jimmunol.180.12.8004
PMCID: PMC3709580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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