Article
The Ets-1 transcription factor is required for the development of natural killer cells in mice.
Immunity - 1 Oct 1998
Barton K, Muthusamy N, Fischer C, Ting C N, Walunas T L, Lanier L L, Leiden J M
Abstract excerpt
In this report we have investigated the role of the Ets-1 transcription factor in the differentiation of the NK cell lineage in mice. Splenic NK cells express high levels of Ets-1. Ets-1-deficient mice produced by gene targeting developed mature erythrocytes, monocytes, neutrophils, and T and B l...
Topics
- Animals
- Cell Differentiation
- Cytokines
- Cytotoxicity, Immunologic
- Female
- Hematopoiesis
- In Vitro Techniques
- Killer Cells, Natural
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neoplasms, Experimental
- Phenotype
- Proto-Oncogene Protein c-ets-1
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ets
- Receptors, Cytokine