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Article

Diverse roles for T-bet in the effector responses required for resistance to infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Harms Pritchard Gretchen, Hall Aisling O'Hara, Christian David A, Wagage Sagie, Fang Qun, Muallem Gaia, John Beena, Glatman Zaretsky Arielle, Dunn William G, Perrigoue Jacqueline, Reiner Steven L, Hunter Christopher A

Abstract excerpt

The transcription factor T-bet has been most prominently linked to NK and T cell production of IFN-γ, a cytokine required for the control of a diverse array of intracellular pathogens. Indeed, in mice challenged with the parasite Toxoplasma gondii, NK and T cell responses are characterized by marked increases of T-bet expression. Unexpectedly, T-bet(-/-) mice infected with T. gondii develop a strong NK cell IFN-γ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25556247
DOI: 10.4049/jimmunol.1401617
PMCID: PMC4297724

Genes

CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Diverse roles for T-bet in the effector responses required for resistance to infection.PMID 25556247Read ↗

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