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Article

Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.

Leukemia - 1 Sept 2018

Ali Ahmed Y, Wu Xun, Eissa Nour, Hou Sen, Ghia Jean-Eric, Murooka Thomas T, Banerji Versha, Johnston James B, Lin Francis, Gibson Spencer B, Marshall Aaron J

Abstract excerpt

The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their interaction with tissue-resident stromal cells. While the PI3Kδ-specific inhibitor idelalisib shows efficacy in treatment of CLL and other B cell malignancies, the function of PI3Kγ has not been extensively studied in B cells. Here, we assess whether PI3Kγ...

Topics

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CD40 Ligand
Chemokines
Leukemia, B-Cell
Lymphoma, B-Cell
Phosphoinositide-3 Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ZAP-70 Protein-Tyrosine Kinase

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Open in PubMed Open full text

Identifiers

PMID: 29479062
DOI: 10.1038/s41375-018-0012-5
PMCID: PMC6127087

Genes

BCR
CXCL12
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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