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Article

Targeted deletion of Vegfa in adult mice induces vision loss

24 Oct 2012

Abstract excerpt

Current therapies directed at controlling vascular abnormalities in cancers and neovascular eye diseases target VEGF and can slow the progression of these diseases. While the critical role of VEGF in development has been well described, the function of locally synthesized VEGF in the adult eye is incompletely understood. Here, we show that conditionally knocking out Vegfa in adult mouse retinal pigmented...

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PMID: 23093773
DOI: 10.1172/jci65157

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