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Article

Generation of transgenic mice with mild and severe retinal neovascularisation.

The British journal of ophthalmology - 1 Jul 2005

Lai C-M, Dunlop S A, May L A, Gorbatov M, Brankov M, Shen W-Y, Binz N, Lai Y Ky, Graham C E, Barry C J, Constable I J, Beazley L D, Rakoczy E P

Abstract excerpt

AIM: To generate a mouse model for slow progressive retinal neovascularisation through vascular endothelial growth factor (VEGF) upregulation. METHODS: Transgenic mice were generated via microinjection of a DNA construct containing the human VEGF165 (hVEGF) gene driven by a truncated mouse rhodopsin promoter. Mouse eyes were characterised clinically and histologically and ocular hVEGF levels assayed by ELISA....

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Identifiers

PMID: 15965177
DOI: 10.1136/bjo.2004.059089
PMCID: PMC1772733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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