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Article

Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction.

Investigative ophthalmology & visual science - 20 May 2014

Nagai Norihiro, Lundh von Leithner Pete, Izumi-Nagai Kanako, Hosking Brett, Chang Bo, Hurd Ron, Adamson Peter, Adamis Anthony P, Foxton Richard H, Ng Yin Shan, Shima David T

Abstract excerpt

PURPOSE: Characterization of a mouse model of spontaneous choroidal neovascularization (sCNV) and its effect on retinal architecture and function. METHODS: The sCNV mouse phenotype was characterized by using fundus photography, fluorescein angiography, confocal scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), ERG, immunostaining, biochemistry, and electron microscopy. A role for VEGF-A...

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Identifiers

PMID: 24845632
DOI: 10.1167/iovs.14-13989
PMCID: PMC4059080

Genes

ERG
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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