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Article

VEGFR1–mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy

22 Dec 2009

Abstract excerpt

VEGF coordinates complex regulation of cellular regeneration and interactions between endothelial and perivascular cells; dysfunction of the VEGF signaling system leads to retinopathy. Here, we show that systemic delivery of VEGF and placental growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature through the VEGF receptor 1...

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Share to Angiogenesis and VEGF in Cancer
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20080765
DOI: 10.1073/pnas.0911661107

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