Article
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2008
Sfanos Karen Sandell, Bruno Tullia C, Maris Charles H, Xu Lauren, Thoburn Christopher J, DeMarzo Angelo M, Meeker Alan K, Isaacs William B, Drake Charles G
Abstract excerpt
PURPOSE: Pathologic examination of prostate glands removed from patients with prostate cancer commonly reveals infiltrating CD4+ and CD8+ T cells. Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer. EXPERIMENTAL DESIGN: We developed a technique that samples the majority of the peripheral prostate...
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