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Article

Human prostate‐infiltrating CD8 <sup>+</sup> T lymphocytes are oligoclonal and PD‐1 <sup>+</sup>

7 Aug 2009

Abstract excerpt

BACKGROUND: Prostate-infiltrating CD8(+) T lymphocytes (CD8(+) PIL) are prevalent in men with prostate cancer (PCa), however, it is unclear whether the presence of such cells reflects a non-specific immune infiltrate or an oligoclonal, antigen-driven adaptive immune response. METHODS: We investigated the complexity of the T-cell receptor (TCR) repertoire in the prostate gland by examining the diversity of CD8(+)...

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PMID: 19670224
DOI: 10.1002/pros.21020

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