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Article

Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2024

Dallos Matthew C, Obradovic Aleksandar Z, McCann Patrick, Chowdhury Nivedita, Pratapa Aditya, Aggen David H, Gaffney Christopher, Autio Karen A, Virk Renu K, De Marzo Angelo M, Antonarakis Emmanuel S, Scher Howard I, Drake Charles G, Rathkopf Dana E

Abstract excerpt

PURPOSE: Androgen deprivation therapy (ADT) remains the backbone of prostate cancer treatment. Beyond the suppression of testosterone and tumor cell growth, emerging evidence suggests that ADT also modulates the immune tumor microenvironment. However, a more precise understanding of the timing and intricacies of these immunologic shifts is needed. EXPERIMENTAL DESIGN: In this study, we analyzed 49 primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39269310
DOI: 10.1158/1078-0432.CCR-24-0060

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