Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.

doi:10.1158/1078-0432.CCR-07-4725

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Article

Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2008

Cattelani Sara, Defferrari Raffaella, Marsilio Sonia, Bussolari Rita, Candini Olivia, Corradini Francesca, Ferrari-Amorotti Giovanna, Guerzoni Clara, Pecorari Luisa, Menin Chiara, Bertorelle Roberta, Altavista Pierluigi, McDowell Heather P, Boldrini Renata, Dominici Carlo, Tonini Gian Paolo, Raschellà Giuseppe, Calabretta Bruno

Abstract excerpt

PURPOSE: MDM2 is a key negative regulator of p53 activity, and a single nucleotide polymorphism (SNP309, T>G change; rs 2279744) in its promoter increases the affinity for the transcription factor SP1, enhancing MDM2 expression. We carried out a pilot study to investigate the effect of this polymorphism on development and behavior of neuroblastoma, an extracranial pediatric tumor with unfrequent genetic...

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PMID: 18519749
DOI: 10.1158/1078-0432.CCR-07-4725

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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