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Article

Impact of MDM2 SNP309 genotype on progression and survival of stage 4 neuroblastoma.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2008

Perfumo C, Parodi S, Mazzocco K, Defferrari R, Inga A, Haupt R, Fronza G, Tonini G P

Abstract excerpt

Circumvention of the p53 checkpoint in neuroblastoma (NB) might arise from increased expression of its main negative regulator MDM2. The SNP309, a T-to-G substitution in the MDM2 promoter, was associated with higher levels of MDM2 mRNA and protein, with consequent attenuation of the p53 pathway. The association between MDM2 SNP309 and disease progression and survival was evaluated in a cohort of 142 children with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18835771
DOI: 10.1016/j.ejca.2008.08.018

Genes

MDM2
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impact of MDM2 SNP309 genotype on progression and survival of stage 4 neuroblastoma.PMID 18835771Read ↗

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