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Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.

Medicine - 1 Mar 2016

Zhuo Xianlu, Ye Huiping, Li Qi, Xiang Zhaolan, Zhang Xueyuan

Abstract excerpt

Murine double minute-2 (MDM2) is a negative regulator of P53, and its T309G polymorphism has been suggested as a risk factor for a variety of cancers. Increasing evidence has shown the association of MDM2 T309G polymorphism with head and neck carcinoma (HNC) risk. However, the results are inconsistent. Thus, we performed a meta-analysis to elucidate the association. The meta-analysis retrieved studies published...

Topics

Biomarkers, Tumor
Carcinoma
Genetic Markers
Genetic Predisposition to Disease
Head and Neck Neoplasms
Humans
Models, Statistical
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms
Odds Ratio
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-mdm2

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26945408
DOI: 10.1097/MD.0000000000002948
PMCID: PMC4782892

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.PMID 26945408Read ↗

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