Article
MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma.
Pediatric blood & cancer - 1 Oct 2009
Perfumo Chiara, Parodi Stefano, Mazzocco Katia, Defferrari Raffaella, Inga Alberto, Scarrà Giovanna Bianchi, Ghiorzo Paola, Haupt Riccardo, Tonini Gian Paolo, Fronza Gilberto
Abstract excerpt
BACKGROUND: MDM2 is a major negative regulator of p53 function and is directly regulated by MYCN in neuroblastoma (NB) cells. MDM2 SNP309, a T-to-G substitution in the MDM2 promoter associated with higher gene expression compared to wild-type, may attenuate the p53 pathway in NB, in which p53 mutations are rare. We investigated its impact on NB development and survival in relation with major clinical and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.