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Article

Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.

Journal of virology - 1 May 1990

Marcy A I, Yager D R, Coen D M

Abstract excerpt

We have derived Vero cell lines containing the herpes simplex virus DNA polymerase (pol) gene that complement temperature-sensitive pol mutants. These cell lines were used to recover viruses containing new mutations at the pol locus. Two spontaneously arising host-range mutants, 6C4 and 7E4, were isolated. These mutants did not grow efficiently on Vero cells or synthesize late polypeptides but formed plaques on a...

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Identifiers

PMID: 2157881
DOI: 10.1128/JVI.64.5.2208-2216.1990
PMCID: PMC249381

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