Article
Identification of a DNA encapsidation sequence for human polyomavirus pseudovirion formation.
Journal of medical virology - 1 Jul 2001
Ou W C, Hseu T H, Wang M, Chang H, Chang D
Abstract excerpt
Human polyomavirus is a naked capsid virus containing a closed circular double-stranded DNA genome. The mechanism of DNA encapsidation for the viral progeny formation is not fully understood. In this study, DNA encapsidation domain of the major capsid protein, VP1, of the human polyomavirus JCV was investigated. When the first 12 amino acids were deleted, the E. coli expressed VP1 (Delta N12VP1) failed to...
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