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Article

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.

Biochimica et biophysica acta - 1 Oct 2008

He Hong, Shulkes Arthur, Baldwin Graham S

Abstract excerpt

Beta-catenin regulates cell-cell adhesion by binding to E-cadherin at the cell membrane and, when translocated into the nucleus, mediates signalling by activation of transcription factors such as TCF4. Mutations of the components of the Wnt/beta-catenin pathway are found in many gastrointestinal cancers. Gastrins, including amidated (Gamide) and glycine-extended (Ggly) gastrin(17), stimulate the proliferation of...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18515095
DOI: 10.1016/j.bbamcr.2008.04.016

Genes

PAK1
TCF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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