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Therapeutic Potential of Targeting PAK Signaling

2 Nov 2015

Abstract excerpt

The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human trails (PF-3758309). The best studied functional roles of PAK proteins are control of cell...

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PMID: 26081410
DOI: 10.2174/1871520615666150617111414

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