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Article

Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.

The Journal of clinical investigation - 1 Aug 2000

Koh T J, Bulitta C J, Fleming J V, Dockray G J, Varro A, Wang T C

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most colorectal cancers and lead to activation of beta-catenin. Whereas several downstream targets of beta-catenin have been identified (c-myc, cyclin D1, PPARdelta), the precise functional significance of many of these targets has not been examined directly using genetic approaches. Previous studies have shown that the gene encoding...

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Share to Adenomatous Polyposis Coli
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

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Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 10953028
DOI: 10.1172/JCI9476
PMCID: PMC380254

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.PMID 10953028Read ↗

Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal TumorigenesisSemantic proximity Read ↗

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.Semantic proximity Read ↗

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc ExpressionSemantic proximity Read ↗

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.Semantic proximity Read ↗

Period 2 mutation accelerates ApcMin/+ tumorigenesis.Semantic proximity Read ↗

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