Article

Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancer

2021-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Second cause of death due to cancer worldwide, colorectal cancer (CRC) is a major public health issue. The discovery of new therapeutic targets is thus essential. The pseudokinase PTK7 intervenes in the regulation of the Wnt/β-catenin pathway signaling, in part, through a kinase-domain dependent interaction with the β-catenin protein. PTK7 is overexpressed in CRC; an event associated with metast...

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Literature Corpus work: b29e1e18-f1ff-5f6d-8756-1df6458451a9
DOI: 10.1101/2021.10.15.464507

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