Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.

Oncogene - 24 Jul 2003

Spicer James, Rayter Sydonia, Young Neville, Elliott Richard, Ashworth Alan, Smith Darrin

Abstract excerpt

Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the ph...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to beta Catenin
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to HeLa Cells

Share to Peutz-Jeghers Syndrome

Share to Wnt Proteins

Share to Zebrafish Proteins

Source

Identifiers

PMID: 12879020
DOI: 10.1038/sj.onc.1206669

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12879020-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.PMID 12879020Read ↗

LKB1, a protein kinase regulating cell proliferation and polaritySemantic proximity Read ↗

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.Semantic proximity Read ↗

Controlling the master-upstream regulation of the tumor suppressor LKB1.Semantic proximity Read ↗

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.Semantic proximity Read ↗

The molecular mechanisms that underlie the tumor suppressor function of LKB1.Semantic proximity Read ↗

Molecular mechanisms of tumor suppression by LKB1.Semantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

LKB1 catalytic activity contributes to estrogen receptor alpha signaling.Semantic proximity Read ↗

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.Semantic proximity Read ↗

LKB1, the multitasking tumour suppressor kinaseSemantic proximity Read ↗

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisSemantic proximity Read ↗

The molecular basis and clinical aspects of Peutz-Jeghers syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.