Article
The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.
Gastroenterology - 1 Jul 2008
Miele Luca, Beale Gary, Patman Gillian, Nobili Valerio, Leathart Julian, Grieco Antonio, Abate Marilena, Friedman Scott L, Narla Goutham, Bugianesi Elisabetta, Day Christopher P, Reeves Helen L
Abstract excerpt
BACKGROUND & AIMS: Although nonalcoholic fatty liver disease (NAFLD) is increasingly common, only a minority of affected individuals develop fibrotic liver disease. Based on its role in liver growth and repair, we explored whether Kruppel-like factor 6 (KLF6) plays a role in NAFLD progression. METHODS: KLF6 expression in 31 fibrosis scored NAFLD liver biopsy specimens was assessed by real-time polymerase chain...
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