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Article

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity.

Hepatology (Baltimore, Md.) - 1 Feb 2015

Sookoian Silvia, Castaño Gustavo O, Scian Romina, Mallardi Pablo, Fernández Gianotti Tomas, Burgueño Adriana L, San Martino Julio, Pirola Carlos J

Abstract excerpt

UNLABELLED: We explored the role of transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and disease severity. A total of 361 individuals (135 control subjects and 226 patients with histologically proven NAFLD) were included in a sample with 97% power for the additive genetic model. A discrete trait...

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Source

Identifiers

PMID: 25302781
DOI: 10.1002/hep.27556

Genes

PNPLA3

Variants

rs58542926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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