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Article

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.

Hepatology (Baltimore, Md.) - 1 Jul 2016

Eslam Mohammed, Mangia Alessandra, Berg Thomas, Chan Henry Lik Yuen, Irving William L, Dore Gregory J, Abate Maria Lorena, Bugianesi Elisabetta, Adams Leon A, Najim Mustafa A M, Miele Luca, Weltman Martin, Mollison Lindsay, Cheng Wendy, Riordan Stephen, Fischer Janett, Romero-Gomez Manuel, Spengler Ulrich, Nattermann Jacob, Rahme Antony, Sheridan David, Booth David R, McLeod Duncan, Powell Elizabeth, Liddle Christopher, Douglas Mark W, van der Poorten David, George Jacob

Abstract excerpt

UNLABELLED: A genome-wide exome association study has identified the transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 variant encoding an E167K substitution as a genetic determinant of hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). The roles of this variant across a spectrum of liver diseases and pathologies and on serum lipids comparing viral hepatitis to NAFLD and viral load in chronic...

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PMID: 26822232
DOI: 10.1002/hep.28475

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Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.PMID 26822232Read ↗

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