Article
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) - 1 Apr 2012
Bechmann Lars P, Gastaldelli Amalia, Vetter Diana, Patman Gillian L, Pascoe Laura, Hannivoort Rebekka A, Lee Ursula E, Fiel Isabel, Muñoz Ursula, Ciociaro Demetrio, Lee Young-Min, Buzzigoli Emma, Miele Luca, Hui Kei Y, Bugianesi Elisabetta, Burt Alastair D, Day Christopher P, Mari Andrea, Agius Loranne, Walker Mark, Friedman Scott L, Reeves Helen L
Abstract excerpt
UNLABELLED: The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD). To explore a potential role for KLF6 in the development of insulin resistance, central to NAFLD pathogenesis, we genotyped KLF6-IVS1-27 in healthy subjects and...
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