Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.

The EMBO journal - 18 Jun 2008

Oguma Keisuke, Oshima Hiroko, Aoki Masahiro, Uchio Ryusei, Naka Kazuhito, Nakamura Satoshi, Hirao Atsushi, Saya Hideyuki, Taketo Makoto Mark, Oshima Masanobu

Abstract excerpt

The activation of Wnt/beta-catenin signalling has an important function in gastrointestinal tumorigenesis. It has been suggested that the promotion of Wnt/beta-catenin activity beyond the threshold is important for carcinogenesis. We herein investigated the role of macrophages in the promotion of Wnt/beta-catenin activity in gastric tumorigenesis. We found beta-catenin nuclear accumulation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3 beta

Share to Helicobacter Infections

Share to Macrophage Activation

Share to Precancerous Conditions

Share to Stomach

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18511911
DOI: 10.1038/emboj.2008.105
PMCID: PMC2413189

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.PMID 18511911Read ↗

Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages.Semantic proximity Read ↗

Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancerSemantic proximity Read ↗

Inflaming gastrointestinal oncogenic programming.Semantic proximity Read ↗

Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injurySemantic proximity Read ↗

NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and MERTK-Mediated Efferocytosis.Semantic proximity Read ↗

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.Semantic proximity Read ↗

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injurySemantic proximity Read ↗

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formationSemantic proximity Read ↗

β-Catenin/Wnt Signaling Regulates Expression of the Membrane Type 3 Matrix Metalloproteinase in Gastric CancerSemantic proximity Read ↗

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.