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Article

NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and MERTK-Mediated Efferocytosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Aug 2026

Haile Shambel Araya, Gatta Alessandra, Colon Nina, Philpott Dana J, Kufer Thomas A, Ying Le, Tong Dongmei, Ferrero Richard L

Abstract excerpt

The innate immune protein NLRC5 plays a key role in cancer immune surveillance. Reduced NLRC5 expression is associated with a poor prognosis for many types of cancers. Previously, we showed that mice with a myeloid-specific deletion of Nlrc5 (Nlrc5mø-KO) develop gastric lymphoid lesions to Helicobacter infection resembling early-stage marginal zone lymphoma. We hypothesized that NLRC5 deficiency may promote a...

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Share to Axl Receptor Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 42541333
DOI: 10.1096/fj.202504879R
PMCID: PMC13428295

Genes

NLRC5
MERTK
AXL
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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