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Article

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

4 Jun 2012

Abstract excerpt

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this...

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PMID: 22665058
DOI: 10.1038/onc.2012.224

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