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Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer

1 Sept 2001

Abstract excerpt

WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A and WNT6, which are clustered in human chromosome 2q35 region. In this study, we investigated expression of WNT10A and WNT6 in gastric cancer. The 3.0- and 2.4-kb WNT10A mRNAs were expressed in gastric cancer cell lines MKN7, MKN45 and MKN74. The 2.0-kb WNT6 mRNA was expressed in gastric...

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PMID: 11494032
DOI: 10.3892/ijo.19.3.533

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