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Article

Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine.

Experimental parasitology - 1 Sept 2008

Coelho Adriano C, Gentil Luciana G, da Silveira José Franco, Cotrim Paulo C

Abstract excerpt

Pentamidine is a second-line agent used in the treatment of leishmaniasis and its mode of action and mechanism of resistance is not well understood. It was previously demonstrated that transfection of promastigotes and amastigotes with the ABC transporter PRP1 gene confers resistance to pentamidine. To further clarify this point, we generated Leishmania amazonensis mutants resistant to pentamidine. Our results...

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PMID: 18511047
DOI: 10.1016/j.exppara.2008.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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