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Article

MRPA-independent mechanisms of antimony resistance in Leishmania infantum.

International journal for parasitology. Drugs and drug resistance - 1 Aug 2020

Douanne Noélie, Wagner Victoria, Roy Gaetan, Leprohon Philippe, Ouellette Marc, Fernandez-Prada Christopher

Abstract excerpt

Control of both human and canine leishmaniasis is based on a very short list of chemotherapeutic agents, headed by antimonial derivatives (Sb). The utility of these molecules is severely threatened by high rates of drug resistance. The ABC transporter MRPA is one of the few key Sb resistance proteins described to date, whose role in detoxification has been thoroughly studied in Leishmania parasites. Nonetheless,...

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Identifiers

PMID: 32413766
DOI: 10.1016/j.ijpddr.2020.03.003
PMCID: PMC7225602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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