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Article

Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.

The Journal of biological chemistry - 23 Jul 2004

Gourbal Benjamin, Sonuc Niluefer, Bhattacharjee Hiranmoy, Legare Danielle, Sundar Shyam, Ouellette Marc, Rosen Barry P, Mukhopadhyay Rita

Abstract excerpt

Leishmaniasis is a protozoan parasitic disease that affects 12 million people worldwide. The first line choice for the treatment of this disease is antimonial drugs. In the endemic regions, resistance to this class of drugs is a major impediment to treatment. Microbes often become resistant to drugs by mutation or down-regulation of uptake systems, but the uptake system for the antimonial drugs in Leishmania is...

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Identifiers

PMID: 15138256
DOI: 10.1074/jbc.M403959200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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