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Article

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.

Cellular and molecular life sciences : CMLS - 1 Sept 2016

Graf Fabrice E, Ludin Philipp, Arquint Christian, Schmidt Remo S, Schaub Nadia, Kunz Renggli Christina, Munday Jane C, Krezdorn Jessica, Baker Nicola, Horn David, Balmer Oliver, Caccone Adalgisa, de Koning Harry P, Mäser Pascal

Abstract excerpt

Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b. rhodesiense that have been selected with the drugs melarsoprol and pentamidine over the course of 2 years, until they exhibited stable cross-resistance to an unprecedented degree. We...

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Identifiers

PMID: 26973180
DOI: 10.1007/s00018-016-2173-6
PMCID: PMC4967103

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AQP2

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