Article
Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.
PLoS neglected tropical diseases - 1 Aug 2016
Eze Anthonius A, Gould Matthew K, Munday Jane C, Tagoe Daniel N A, Stelmanis Valters, Schnaufer Achim, De Koning Harry P
Abstract excerpt
BACKGROUND: Isometamidium is the main prophylactic drug used to prevent the infection of livestock with trypanosomes that cause Animal African Trypanosomiasis. As well as the animal infective trypanosome species, livestock can also harbor the closely related human infective subspecies T. b. gambiense and T. b. rhodesiense. Resistance to isometamidium is a growing concern, as is cross-resistance to the diamidine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.