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Article

Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes. Modulation of the resistance during in-vitro developmental life cycle.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Dec 1997

Sereno D, Michon P, Brajon N, Lemesre J L

Abstract excerpt

Two clones of Leishmania mexicana resistant to 5 microM (LmR5CL2) and 20 microM (LmR20CL1) pentamidine, derived from a parental wild-type clone (LmWTCL3) were selected in vitro using a continuous drug pressure protocol. Both resistant clones expressed a cross-resistance to diminazene aceturate. No differences in their in-vitro infectivity for mouse peritoneal macrophages between wild-type and...

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PMID: 9587476
DOI: 10.1016/s0764-4469(97)82471-7

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