Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

doi:10.1093/jac/dkt442

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Article

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

The Journal of antimicrobial chemotherapy - 1 Mar 2014

Munday Jane C, Eze Anthonius A, Baker Nicola, Glover Lucy, Clucas Caroline, Aguinaga Andrés David, Natto Manal J, Teka Ibrahim A, McDonald Jennifer, Lee Rebecca S, Graf Fabrice E, Ludin Philipp, Burchmore Richard J S, Turner C Michael R, Tait Andy, MacLeod Annette, Mäser Pascal, Barrett Michael P, Horn David, De Koning Harry P

Abstract excerpt

OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin 2 (TbAQP2) caused melarsoprol/pentamidine cross-resistance (MPXR) in these parasites and the current study aims to delineate the mechanism by which this occurs....

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Identifiers

PMID: 24235095
DOI: 10.1093/jac/dkt442
PMCID: PMC3922157

Genes

AQP2
AQP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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