Article
Efficacy of second line drugs on antimonyl-resistant amastigotes of Leishmania infantum.
Acta tropica - 5 Jan 2000
Sereno D, Holzmuller P, Lemesre J L
Abstract excerpt
In a previous paper we have demonstrated that the induction, by direct drug pressure, of a resistance to Sb(III) antimony at physiological concentration in the amastigote stage of the parasite, led to a high cross-resistance to Sb(V) species in the form of Glucantime. In this paper, further chemoresistant clones were characterized. Axenic amastigotes of Leishmania infantum were adapted to survive in culture...
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