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Article

Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells.

The Journal of biological chemistry - 3 Dec 2010

Zhang Li, Jin Min, Margariti Andriana, Wang Gang, Luo Zhenling, Zampetaki Anna, Zeng Lingfang, Ye Shu, Zhu Jianhua, Xiao Qingzhong

Abstract excerpt

We have previously demonstrated that histone deacetylase 7 (HDAC7) expression and splicing play an important role in smooth muscle cell (SMC) differentiation from embryonic stem (ES) cells, but the molecular mechanisms of increased HDAC7 expression during SMC differentiation are currently unknown. In this study, we found that platelet-derived growth factor-BB (PDGF-BB) induced a 3-fold increase in the transcripts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20889501
DOI: 10.1074/jbc.M110.153999
PMCID: PMC2992279

Genes

HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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