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Article

Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2013

Kaluza David, Kroll Jens, Gesierich Sabine, Manavski Yosif, Boeckel Jes-Niels, Doebele Carmen, Zelent Arthur, Rössig Lothar, Zeiher Andreas M, Augustin Hellmut G, Urbich Carmen, Dimmeler Stefanie

Abstract excerpt

OBJECTIVE: Histone deacetylases (HDACs) modulate gene expression by deacetylation of histone and nonhistone proteins. Several HDACs control angiogenesis, but the role of HDAC9 is unclear. METHODS AND RESULTS: Here, we analyzed the function of HDAC9 in angiogenesis and its involvement in regulating microRNAs. In vitro, silencing of HDAC9 reduces endothelial cell tube formation and sprouting. Furthermore, HDAC9...

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Source

Identifiers

PMID: 23288173
DOI: 10.1161/ATVBAHA.112.300415

Genes

HDAC9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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