Article
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation.
The Journal of biological chemistry - 10 Oct 2003
Yahata Yoko, Shirakata Yuji, Tokumaru Sho, Yamasaki Kenshi, Sayama Koji, Hanakawa Yasushi, Detmar Michael, Hashimoto Koji
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a potent, multifunctional, endothelial-cell-specific growth factor. It stimulates proliferation and migration of endothelial cells. Characterization of intracellular signal transduction after VEGF and VEGF receptor (VEGFR) interaction has demonstrated the involvement of the mitogen-activated protein kinase pathway. However, several studies indicated that signal...
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