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Article

Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.

The Journal of biological chemistry - 24 Feb 2006

Bunch Thomas A, Helsten Teresa L, Kendall Timmy L, Shirahatti Nikhil, Mahadevan Daruka, Shattil Sanford J, Brower Danny L

Abstract excerpt

We developed a ligand-mimetic antibody Fab fragment specific for Drosophila alphaPS2betaPS integrins to probe the ligand binding affinities of these invertebrate receptors. TWOW-1 was constructed by inserting a fragment of the extracellular matrix protein Tiggrin into the H-CDR3 of the alphavbeta3 ligand-mimetic antibody WOW-1. The specificity of alphaPS2betaPS binding to TWOW-1 was demonstrated by numerous tests...

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Identifiers

PMID: 16371365
DOI: 10.1074/jbc.M508550200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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