Article
p53 mutations and expression in breast carcinoma in situ.
The American journal of pathology - 1 Jan 2000
Lukas J, Niu N, Press M F
Abstract excerpt
The p53 tumor suppressor gene is altered in approximately half of human cancers. Although p53 mutations are common in invasive breast carcinoma, few have been identified in breast carcinoma in situ (intraductal breast carcinomas). Most studies of p53 in breast carcinoma in situ are immunohistochemical studies of p53 staining in paraffin-embedded tissue sections. Few studies have isolated the tumor cells and...
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